I’m skeeved out by how dehumanized the two villains are in in Family Remains. I've only once heard this talked about in fandom, and in a very limited sense: A fan (a Dean fan, of course) rightfully criticized Sam for describing them as barely human. But it goes beyond Sam. The narrative itself portrays them as subuman animals.
I find this disturbing, because incest and abuse are things that happen in real life. They are topics that are already wreathed in shame. And here we have a story about children conceived from incest who are subhuman. I am not OK with that.